10 Best-Selling Infectious Disease Books Millions Love

Top picks by Bill Gates, Jon Najarian, and Jeff Dean reveal best-selling Infectious Disease books with expert-approved insights

Bill Gates
Jon Najarian
Jeff Dean (@)
Pierre Haski
Indra Nooyi
Vali Nasr
Kyle Bass
Updated on June 24, 2025
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When millions of readers and leading experts converge on a select group of books, it signals something special. Infectious disease remains a critical global concern, and these 10 best sellers have consistently offered readers both gripping stories and valuable insights into pandemics, outbreaks, and the science behind them.

Experts like Bill Gates, known for his philanthropic focus on global health, and Jon Najarian, a CNBC anchor with deep interest in viral outbreaks, have recommended titles such as The Hot Zone and Infections and Inequalities. Their endorsements reflect the books' power to illuminate complex topics in accessible ways. For instance, Gates' focus on social determinants is evident in his support for Paul Farmer's work, while Najarian's interest in viral origins shines through his praise for Richard Preston's narratives.

While these popular books provide proven frameworks and captivating accounts, readers seeking content tailored precisely to their unique Infectious Disease interests might consider creating a personalized Infectious Disease book that blends these validated approaches into a custom learning experience.

Best for gripping outbreak narratives
Jon Najarian, a CNBC anchor and co-founder of Investitute with a background in stock trading and sports, recommends this book for its insightful connection between viruses like coronavirus and Ebola, highlighting its chilling relevance. He notes, "Scary, but great book on ebola: Hot Zone by Richard Preston," reflecting how the book deepened his understanding of viral outbreaks. Similarly, Pierre Haski, a geopolitical commentator and president of Reporters Without Borders, found it a valuable companion during the SARS crisis in Beijing, describing it as "a great book!" Their endorsements underscore the book's impact on both public health awareness and global crises understanding.
JN

Recommended by Jon Najarian

Co-Founder @Investitute, CNBC Anchor, Former NFL Player

I believe both the corona virus and ebola have a bat connection. Scary, but great book on ebola: Hot Zone by Richard Preston (from X)

Richard Preston's decades of experience writing for The New Yorker and his unique access to scientific sources led him to craft a gripping narrative about Ebola's terrifying emergence. You get a detailed look at how this lethal virus surfaced and threatened public health, delivered through vivid storytelling of outbreak investigations and the military's response. The book breaks down complex virology and epidemiology into engaging chapters like the virus's journey from the African rain forest to suburban America. If you're curious about infectious diseases or public health crises, this book offers rare insight without oversimplifying the science or sensationalizing the facts.

New York Times Bestseller
Centers for Disease Control Champion of Prevention Award to Author
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Best for historical pandemic insights
Jeff Dean, Senior Fellow and SVP of Google AI Research and Health, highlights how John M. Barry’s work on the 1918 influenza pandemic resonates deeply amid current health crises. Reflecting on his own experience of social distancing, Dean shares, "Thanks for the pointer, joetimmons79! Also, looks like John Barry, the speaker in the video, is an author, & has an interesting book about the 1918 flu (if flu pandemic books while social distancing is your cup of tea: I've added to my queue)." This recommendation aligns with widespread recognition, affirming the book’s relevance for understanding pandemic dynamics. Additionally, Indra Nooyi, former CEO of PepsiCo, connects the historical analysis to contemporary policy challenges, emphasizing the book’s lens on COVID-19 responses.
JD

Recommended by Jeff Dean

Senior Fellow & SVP, Google AI Research and Health

Thanks for the pointer, joetimmons79! Also, looks like John Barry, the speaker in the video, is an author, & has an interesting book about the 1918 flu (if flu pandemic books while social distancing is your cup of tea: I've added to my queue): (from X)

John M. Barry’s detailed exploration of the 1918 influenza pandemic reveals not just the devastating impact of the virus but also the complex interplay between science, politics, and public trust. You’ll gain insights into how misinformation and leadership decisions shaped the course of the outbreak, with chapters dissecting the virus’s spread through military camps and urban centers. Barry’s background advising government agencies on pandemic response lends the narrative a unique authority, especially in his analysis of non-pharmaceutical interventions. This book is particularly valuable if you want to understand the historical roots of infectious disease management and the critical role transparency plays in public health crises.

New York Times Bestseller
National Academies Outstanding Science Book
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Best for tailored response plans
This AI-created book on infectious disease control is designed around your background, skill level, and specific interests. By sharing what challenges you want to focus on, you receive a tailored guide that dives into the most relevant concepts and practical knowledge. This approach makes complex infectious disease topics more accessible and meaningful, giving you a focused learning experience aligned with your goals.
2025·50-300 pages·Infectious Disease, Epidemiology, Outbreak Investigation, Disease Transmission, Public Health

This tailored book explores infectious disease control through a lens uniquely focused on your interests and background. It covers essential principles of disease transmission, outbreak investigation, and prevention techniques while addressing the specific challenges you face. By blending widely validated knowledge with a customized approach, it reveals how to understand epidemic patterns, public health responses, and emerging threats in a way that fits your goals. This personalized guide helps you engage deeply with critical infectious disease concepts, from epidemiology basics to intervention design, fostering a learning experience that is both relevant and compelling.

Tailored Content
Outbreak Analysis
1,000+ Happy Readers
Best for zoonotic disease understanding
Kaleigh Rogers, a reporter covering politics, tech, and science, highlights Spillover as a standout work in understanding infectious disease. She notes, "Spillover is a fantastic book though. I'd also recommend Pandemic and/or The Fever by @soniashah," reflecting how this book resonates with both experts and broad audiences concerned about pandemic risks. Rogers' endorsement mirrors widespread acclaim, including praise from The Seattle Times, which calls Quammen one of the best science writers, comparing his narrative to Richard Preston’s The Hot Zone. This book helped her grasp the complex reality behind zoonotic diseases and how they might shape our future.
KR

Recommended by Kaleigh Rogers

Reporter covering politics, tech, and science

@rachsyme Spillover is a fantastic book though. I'd also recommend Pandemic and/or The Fever by @soniashah (from X)

David Quammen’s decades of nature writing and science journalism led him to trace the hidden paths of animal-borne diseases threatening humanity. You’ll find detailed narratives about fieldwork capturing bats in China and tracking gorillas in Congo, paired with insights from leading epidemiologists about spillover—the process by which viruses jump from animals to humans. The book dives into diseases like Ebola and SARS, explaining their origins and the global risks they pose. If you want a grounded understanding of how pandemics emerge and what drives these outbreaks, this book offers an engaging blend of storytelling and scientific exploration.

Booklist Top 10 Science Book 2012
New York Times Book Review Notable Book
Daily Beast Top 11 Book 2012
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Best for history and disease impact
Plagues and Peoples stands out in infectious disease literature by exploring the profound influence of disease on human history rather than focusing solely on medical details. This book’s enduring popularity speaks to its unique approach that blends political, demographic, and ecological perspectives to reveal how epidemics have shaped civilizations. By tracing events from smallpox in Mexico to the bubonic plague in China, it offers a compelling framework for understanding the broader consequences of infectious diseases. Anyone interested in the intersection of history and medicine will find this exploration both enlightening and essential.
PG

Recommended by Paul Graham

Co-Founder of Y Combinator

Plagues and Peoples book cover

by William H. McNeill·You?

1977·368 pages·Medicine History, Infectious Disease, History, Epidemiology, Demography

William H. McNeill challenges the conventional wisdom that history unfolds independently of disease, instead positioning epidemics as key drivers shaping societies politically, demographically, and ecologically. Through detailed case studies—from the impact of smallpox in Mexico to the bubonic plague in China—McNeill reveals how infectious diseases have altered the course of civilizations. You’ll gain insight into the profound ways pathogens have influenced human history, offering a lens that connects medical events with cultural and environmental shifts. This book suits anyone intrigued by how disease intersects with global history and the forces behind societal transformations.

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Best for pandemic response analysis
Laura Mcinerney, co-founder of TeacherTapp and former SchoolsWeek editor, praises this book for its vivid portrayal of a public health officer who foresaw the pandemic's trajectory while being ignored. Her endorsement highlights the book’s resonance beyond scientific circles, reflecting broader concerns about institutional response during crises. This perspective aligns with popular acclaim, emphasizing the human stories behind pandemic data. Additionally, Don Moynihan, Georgetown professor, underscores its value as a case study in governmental learning failures, particularly how historical pandemic lessons were overlooked, deepening understanding of infectious disease policy challenges.
LM

Recommended by Laura Mcinerney

Co-Founder of TeacherTapp, former SchoolsWeek editor

@langtrygirl It’s a really good book. You’ll love one character: a little public health woman, around 40, who was completely correct about it all and kept being ignored. I almost want this as a tattoo: (from X)

2021·320 pages·Infectious Disease, Epidemic, Contagious Disease, Infectious Diseases, Pandemic Response

Michael Lewis, known for his sharp narratives on complex systems, turns his attention to infectious disease with a gripping examination of the early COVID-19 pandemic response. You gain insight into the clash between scientific foresight and political inertia, spotlighting unsung public health figures like a local officer whose observations expose systemic blind spots. The book dives into the real-world challenges of pandemic preparedness and institutional failure, revealing how expertise can be sidelined amid misinformation. If you're interested in the intersection of science, policy, and crisis management, this narrative offers a clear-eyed look at what happens when knowledge meets bureaucracy.

New York Times Bestseller
American Scientist Science Book of 2021
One of Smithsonian's 10 Best Science Books of 2021
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Best for rapid action plans
This AI-created book on pandemic response is crafted based on your background, skill level, and specific infectious disease interests. You share which aspects you want to focus on and your goals, so the book covers exactly the steps and knowledge you need. Such customization makes sense here because pandemic management requires precise, actionable understanding tailored to your unique context and urgency.
2025·50-300 pages·Infectious Disease, Pandemic Response, Outbreak Control, Virus Transmission, Public Health

This tailored book explores a 90-day system designed to rapidly apply key infectious disease insights for practical, impactful results. It examines crucial steps in outbreak response, virus containment, and public health interventions, focusing on your individual background and goals. By aligning content with your interests and experience, it offers a personalized pathway to understanding and acting swiftly during infectious disease events. The book covers essential topics such as pandemic dynamics, transmission control, and emergency preparedness, ensuring you gain knowledge that matches your specific needs. This tailored approach helps you navigate complex infectious disease challenges efficiently and confidently, transforming valuable concepts into actionable understanding.

Tailored Guide
Rapid Response Insights
3,000+ Books Generated
Best for Ebola outbreak coverage
Elizabeth Kolbert, Pulitzer Prize-winning author known for her work on environmental crises, highlights the urgent relevance of this book amid growing global health concerns. She emphasizes how "Crisis in the Red Zone reads like a thriller. That the story it tells is all true makes it all more terrifying," underscoring the book's powerful impact. This recommendation aligns with widespread reader acclaim for Preston's vivid portrayal of the 2013–2014 Ebola outbreak, challenging assumptions and deepening understanding of infectious disease threats.

Recommended by Elizabeth Kolbert

Pulitzer Prize-winning author

Crisis in the Red Zone reads like a thriller. That the story it tells is all true makes it all more terrifying, and there’s no one who could tell it better than Richard Preston.

What happens when a seasoned science writer turns his attention to the deadliest Ebola outbreak? Richard Preston, with his background as the #1 New York Times bestselling author known for vividly chronicling infectious diseases, brings you a gripping, fact-driven narrative of the 2013–2014 Ebola epidemic. You’ll gain insight into the complex interplay between doctors’ urgent efforts, government responses, and pharmaceutical races amid a global crisis that spread across continents. Through detailed accounts of frontline healthcare workers and ethical dilemmas over experimental treatments, the book immerses you in the stark realities of viral outbreaks and the looming threats emerging from our increasingly interconnected world. This book is especially suited for those wanting a vivid, well-reported look at infectious disease outbreaks beyond dry clinical summaries.

New York Times Bestseller
Recipient of CDC Champion of Prevention Award
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Best for vaccine development history
Science, a renowned scientific publication, highlights this book as an "easily approachable yet factually rich narrative," praising how Oshinsky makes the complex history of polio accessible and engaging. Their endorsement resonates with the widespread reader acclaim this work has earned, especially among those deeply interested in infectious diseases. This perspective is echoed by The Economist, which appreciates how the book uncovers lesser-known stories from the fight against polio, bringing depth to an often simplified narrative. Together, these expert voices showcase how this book broadens understanding of polio's medical and cultural significance.

Recommended by Science

An easily approachable yet factually rich narrative. Oshinsky provides a very readable and enlightening history that also can be appreciated as good storytelling.

Polio: An American Story book cover

by David M. Oshinsky··You?

Drawing from his expertise as a noted historian of modern American politics and society, David M. Oshinsky explores the complex story of polio in America during the 1950s. You learn about the social panic surrounding the disease, the fierce competition between Jonas Salk and Albert Sabin to develop a vaccine, and the role of the National Foundation for Infantile Paralysis in transforming public health fundraising. Oshinsky also sheds light on how the polio crisis influenced government policies on drug approval and liability. If you're interested in medical history, public health, or the cultural impact of disease, this book offers a nuanced perspective that goes beyond simple narratives of triumph.

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Best for Lyme disease controversies
Evolutionary Ecologist, a science writer for Forbes and Medium, recommends this book with enthusiasm: "WHOA!! must-read book! Lyme disease uncovered with gripping detail and expert insight." Her endorsement reflects the book's power to illuminate the mysteries of Lyme disease through a blend of investigative journalism and scientific exploration. This perspective aligns with the widespread interest in understanding this complex infectious disease and its controversial history.
EE

Recommended by Evolutionary Ecologist

Science writer at Forbes and Medium

WHOA!! must-read book! Lyme disease uncovered with gripping detail and expert insight. (from X)

2019·336 pages·Infectious Disease, Infectious Diseases, Biological Weapons, Epidemiology, Microbiology

What started as Kris Newby's personal struggle with Lyme disease transformed into a deep dive into the complex history and controversies surrounding this elusive illness. Drawing on her background as a science writer, Newby unpacks the story of Willy Burgdorfer, the scientist who discovered the Lyme microbe, and explores his secret work on biological weapons during the Cold War. You’ll gain insights into why Lyme disease remains so misunderstood, the challenges in diagnosis and treatment, and the unsettling possibility that a military experiment may have sparked the epidemic. This book suits those curious about infectious diseases, biomedical history, or the intersection of science and government secrecy.

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Best for social determinants focus
This book offers a rare perspective on infectious diseases by intertwining medical expertise with social analysis. It highlights how poverty shapes vulnerability to ailments like AIDS and tuberculosis, challenging common health narratives that oversimplify causes. Its enduring popularity reflects widespread acknowledgment of this approach’s importance for anyone involved in public health or social policy. The author’s frontline experience and commitment to equity make this work a critical contribution to understanding and addressing infectious diseases' broader social context.
BG

Recommended by Bill Gates

Co-Founder & Former CEO of Microsoft

1999·389 pages·Public Health, Infectious Disease, Tropical Medicine, Medicine, Social Inequality

Drawing from his extensive experience as a physician-anthropologist working in Haiti and Peru, Paul Farmer reveals how infectious diseases disproportionately affect the poor due to entrenched social and economic inequalities. You’ll gain insight into the complex interplay between disease and poverty, learning why typical health strategies often miss the root causes of illness. The book challenges you to rethink epidemiology by highlighting systemic factors rather than blaming individuals, with vivid case studies on AIDS, tuberculosis, and malaria. It's particularly suited for anyone interested in global health, social justice, or the broader impacts of infectious disease beyond medicine alone.

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Best for epidemiological modeling
What makes this book unique in infectious disease literature is its integration of mathematical models with broad epidemiological data, providing a framework that has been widely adopted in public health. Published by Oxford University Press, it addresses both microparasites and macroparasites, offering insights crucial for controlling diseases like malaria and HIV. Its analytical approach helps translate complex biological interactions into tools for health strategy, making it invaluable for anyone working in infectious disease research or policy development.
1991·766 pages·Infectious Disease, Infectious Diseases, Epidemiology, Mathematical Modeling, Public Health

Roy M. Anderson and Robert M. May bring their combined expertise in epidemiology and mathematical biology to create a rigorous analysis of infectious diseases. The book offers a detailed exploration of the dynamics between pathogens and host populations, blending mathematical models with extensive epidemiological data to clarify how diseases spread and can be controlled. You'll find chapters that begin with intuitive models for viruses and parasites, gradually building to complex frameworks essential for public health planning, especially concerning diseases like malaria, measles, and emerging viruses such as HIV. If you're involved in epidemiology, public health strategy, or disease modeling, this book equips you with a solid foundation in both theory and application.

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Trusted by infectious disease enthusiasts worldwide

Infectious Disease Blueprint
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Conclusion

This collection underscores three clear themes: the power of storytelling to convey infectious disease realities, the importance of historical and social context in understanding outbreaks, and the value of scientific rigor in addressing pandemics. If you prefer proven methods conveyed through narrative, start with The Hot Zone or The Great Influenza. For validated scientific and social frameworks, combining Infectious Diseases of Humans with Infections and Inequalities offers depth.

For those who want to merge these expert insights with a focus tailored to their specific concerns—whether policy, science, or personal interest—you can create a personalized Infectious Disease book that adapts these proven approaches to your needs. These widely-adopted methods have helped many readers succeed in mastering the complex world of infectious diseases.

Frequently Asked Questions

I'm overwhelmed by choice – which book should I start with?

Start with The Hot Zone for a gripping introduction to infectious diseases through a real outbreak story. It’s engaging and accessible, setting a solid foundation before diving into more technical or historical works.

Are these books too advanced for someone new to Infectious Disease?

Not at all. Many, like The Great Influenza and Spillover, balance storytelling with science, making them suitable for beginners who want both context and clarity.

What's the best order to read these books?

Begin with narrative-driven books like The Hot Zone and The Premonition. Then explore historical and social analyses such as Plagues and Peoples and Infections and Inequalities. Finally, dive into technical texts like Infectious Diseases of Humans.

Do I really need to read all of these, or can I just pick one?

You can pick based on your interest—outbreak stories, history, or science. Each book stands strong alone but together they offer a richer understanding of infectious diseases.

Are any of these books outdated given how fast Infectious Disease changes?

While some focus on historical outbreaks, their lessons remain relevant. Recent works like The Premonition capture modern pandemic challenges, keeping the collection timely and insightful.

How can I get Infectious Disease insights tailored to my specific needs?

These expert books offer valuable knowledge, but personalized content can focus on your unique goals and background. You might consider creating a personalized Infectious Disease book that combines proven methods with your specific interests for efficient learning.

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