Stephen Marder

Daniel X. Freedman Professor of Psychiatry, Vice Chair for Education, Semel Institute for Neuroscience at UCLA; Director, VA VISN 22 Mental Illness Research, Education, and Clinical Center

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Book Recommendations:

Recommended by Stephen Marder

'The use of antipsychotic plasma levels - or therapeutic drug monitoring - is a valuable tool but underutilized by practicing clinicians due to the difficulties in interpretation. The strength of this volume lies in its thoughtful framework for interpreting plasma level information for different antipsychotics for individual patients treated under different circumstances. The book addresses how plasma concentrations can be helpful during long-term maintenance treatment when patients are being treated with oral or long-acting injectable medications. Readers also learn how to differentiate non-adherence from kinetic effects that lower drug levels. For all of these and other clinical circumstances, Meyer and Stahl provide both a scholarly and very accessible approach that can improve the practice of any clinician who prescribes an antipsychotic.' Stephen R. Marder, Daniel X. Freedman Professor of Psychiatry, Vice Chair for Education, Semel Institute for Neuroscience at UCLA; Director, VA VISN 22 Mental Illness Research, Education, and Clinical Center (from Amazon)

Clinicians recognize that monitoring psychotropic levels provides invaluable information to optimize therapy and track treatment adherence, but they lack formal training specifically focused on the use of plasma antipsychotic levels for these purposes. As new technologies emerge to rapidly provide these results, the opportunity to integrate this information into clinical care will grow. This practical handbook clarifies confusing concepts in the literature on use of antipsychotic levels, providing clear explanations for the logic underlying clinically relevant concepts such as the therapeutic threshold and the point of futility, and how these apply to individual antipsychotics. It offers accessible information on the expected correlation between dosages and trough levels, and also provides a clear explanation of how to use antipsychotic levels for monitoring oral antipsychotic adherence, and methods to help clinicians differentiate between poor adherence and variations in drug metabolism. An essential resource for psychiatrists, psychiatric nurse practitioners, and mental health professionals worldwide.